Sex Transm Dis 30(3):257–261. Rheol Acta 43(6):657–669. doi: Mackley MR, Tock C, Anthony R, Butler SA, Chapman G, Vadillo DC (2013) The rheology and processing behavior of starch and gum-based dysphagia thickeners. Cite as. Biomaterials 18(9):677–681. doi: Wine JJ, Joo NS (2004) Submucosal glands and airway defense. Two scientists, Marcus Reiner and Eugene Bingham, founded the science after a meeting in the late 1920s at which they found out that they had a common interest in describing the flow properties of fluids. The uppermost layer has maximum velocity while the bottom layer is stationary. Emulsion Formation, Stability, and Rheology Tharwat F. Tadros 1.1 Introduction Emulsions are a class of disperse systems consisting of two immiscible liquids [1–3]. Rheology is the science of flow and deformation of matter. doi: Boegh M, Baldursdóttir SG, Müllertz A, Nielsen HM (2014) Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption. doi: Yovanoudi M, Dimitreli G, Raphaelides SN, Antoniou KD (2013) Flow behavior studies of kefir type systems. Define rheology, provide examples of fluid pharmaceutical products exhibiting various rheologic behaviors, and describe the application of rheology in the pharmaceutical sciences and practice of … Viscosity. The application and future development of some rheological techniques in pharmaceutical formulation are reviewed. Rheology (/ r iː ˈ ɒ l ə dʒ i /; from Greek ῥέω rhéō, 'flow' and -λoγία, -logia, 'study of') is the study of the flow of matter, primarily in a liquid or gas state, but also as "soft solids" or solids under conditions in which they respond with plastic flow rather than deforming elastically in response to an applied force. The ARES-EVF: Option for measuring extensional viscosity of polymer melts. Polymer 53(15):3220–3229. stability) 4 of 65. Int J Pharm 2(1):27–40. Biopharm Drug Dispos 33(7):403–416. © 2020 Springer Nature Switzerland AG. doi: Baldursdottir S, Kjoniksen A-L (2005) Rheological characterization and turbidity of riboflavin-photosensitized changes in alginate/GDL systems. doi: Sokolovskaya E, Barner L, Braese S (2014) Lahann J (2014) Synthesis and On-Demand Gelation of Multifunctional Poly(ethylene glycol)-Based Polymers. 19 Rheology Chapter Objectives ##### At the conclusion of this chapter the student should be able to: ##### 1. This service is more advanced with JavaScript available, Analytical Techniques in the Pharmaceutical Sciences J Food Eng 118(1):41–48. Part of Springer Nature. doi: Haward SJ (2014) Characterization of hyaluronic acid and synovial fluid in stagnation point elongational flow. Phys Rev Lett 110(16):168301. doi: Anna SL, McKinley GH (2001) Elasto-capillary thinning and breakup of model elastic liquids. Adv Drug Delivery Rev 46(1–3):75–87. Examples of the use of rheological techniques in the pharmaceutical field, as well as other closely related fields such as food and polymer science, are also given. Start studying Physical Pharmacy: Rheology. Proc Am Thorac Soc 1(1):47–53. 2007. Rheology: Concepts, Methods, and Applications, Second Edition is a tool for chemists and chemical engineers to solve many practical problems. Carbohydr Polym 91(2):529–536. J Rheol 25(4):433–443. Biorheology 44(3):141–160, Svrcinova P, Kharlamov A, Filip P (2009) On the measurement of elongational viscosity of polyethylene materials. Marcel Dekker, New York. Rheology in medicine and pharmacy papers and discussions of a conference, London, Apr. J Nanomater 2013:924947. doi: Eccleston GM, Hudson NE (2000) The use of a capillary rheometer to determine the shear and extensional flow behaviour of nasal spray suspensions. Am J Physiol 293(5):L1240–L1249. J Appl Phys 28(5):624–627. Why is rheology important in Pharmacy? Elsevier, London. Liquids that obey Newton’s law of flow are called as Newtonianfluids. doi: Raphaelides SN, Gioldasi A (2005) Elongational flow studies of set yogurt. Food Hydrocolloids 27(1):80–90. Over 10 million scientific documents at your fingertips. doi: Kojarunchitt T, Hook S, Rizwan S, Rades T, Baldursdottir S (2011) Development and characterization of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. Int J Pharm 408(1–2):20–26. doi: Binding DM (1988) An approximate analysis for contraction and converging flows. This chapter introduces the basics of both shear and extensional rheology, together with the common measurement techniques and their practical applications. J Rheol 47(2):429–441. Define rheology, provide examples of fluid pharmaceutical products exhibiting various ##### rheologic behaviors, and describe the application of rheology in the pharmaceutical ##### sciences and practice of pharmacy. doi: Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S (2007) Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. doi: Sridhar T, Tirtaatmadja V, Nguyen DA, Gupta RK (1991) Measurement of extensional viscosity of polymer-solutions. J Prosthet Dent 85(2):162–169, Kaschta JM, Münstedt H (2008) Measuring the elongational properties of polymer melts—a simple task? doi: Morrison FA (2001) Understanding rheology. Importance of rheology in pharmaceutical preparations. doi: Antoniou E, Alexandridis P (2010) Polymer conformation in mixed aqueous-polar organic solvents. For shear flow to … Solids are said to have an ‘elastic’ response, and can resist The rheology has a lot of applications in areas such as food, texture, personal care products, pharmacy, and polymers, among others. WHITHER RHEOLOGY IN PHARMACY? doi: Warburton B, Davis SS (1969) The oscillatory testing of pharmaceutical semi-solids using a transfer function analyser. Rheology is therefore crucially important as it will directly affect the way a drug is formulated and developed, the quality of the raw and finished product, the drug efficacy, the way a patient adheres to the prescribed drug, and the overall healthcare cost. Wiley, New York. Adv Drug Delivery Rev 61(2):101–114. doi: Nelson B (2003) Capillary rheometry. © 2010-2020 PharmaMirror.com - All Rights Reserved. Polymer 45(9):2959–2966. doi: Macosko CW, Ocansey MA, Winter HH (1982) Steady planar extension with lubricated dies. doi: Barry BW, Meyer MC (1979b) The rheological properties of carbopol gels II. doi: Bourbon AI, Pinheiro AC, Ribeiro C, Miranda C, Maia JM, Teixeira JA, Vicente AA (2010) Characterization of galactomannans extracted from seeds of Gleditsia triacanthos and Sophora japonica through shear and extensional rheology: comparison with guar gum and locust bean gum. Pedersen PB, Vilmann P, Bar-Shalom D, Müllertz A, Baldursdottir S (2013) Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities. All normal or Newtonian fluids (air, water, oil, honey) follow the same scientific laws. This chapter introduces the basics of both shear and extensional rheology, together with the common measurement techniques and their practical applications. Email- vijaywaghulkar@gmail.com doi: Rubin BK (2007) Mucus structure and properties in cystic fibrosis. Rheol Acta 52(6):529–546. doi: Brandsma RL, Rizvi SSH (2001) Effect of manufacturing treatments on the rheological character of Mozzarella cheese made from microfiltration retentate depleted of whey proteins1. Semisolid products are the most difficult materials to characterize rheologically because they combine both liquid and solid properties within the same material. II. Further Reading: External Links Examples of Complex Fluids in Pharmaceuticals. Soft Matter 8(2):536–555. J Rheol 55(4):875–900. Polym Eng Sci 11(2):174–176. The subject matter is divided into considerations of powders, suspensions and suspending agents, semi‐solids (creams and ointments), emulsions, suppositories and pessaries, foam aerosols and a general section. Experimental analysis. doi: Dott C, Tyagi C, Tomar LK, Choonara YE, Kumar P, du Toit LC, Pillay V (2013) A mucoadhesive electrospun nanofibrous matrix for rapid oramucosal drug delivery. It's safe and free too. Edited by B. Warburton. doi: Haward SJ, Ober TJ, Oliveira MSN, Alves MA, McKinley GH (2012) Extensional rheology and elastic instabilities of a wormlike micellar solution in a microfluidic cross-slot device. Acta Technica 54:49–57. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Rheology is science which treats the deformation and flow of materials. Rheol Acta 47(5–6):621–642. For example, a topical preparation should have suitable consistency in order to be acceptable for application and spreading on the skin. 1970-07-01 00:00:00 (Received 27 February, 1970) Abstract. Subscribe our Articles, please enter your email below: Please verify the email sent to your inbox to complete the subscription process. Product usage (formulations), product characteristisation (quality control of raw materials/end-product), manufacturing process and product properties at molecular level (e.g. doi: Olmsted SS, Meyn LA, Rohan LC, Hillier SL (2003) Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis. Barry BW, Meyer MC (1979a) The rheological properties of carbopol gels. doi: Mao Y, McClements DJ (2012a) Fabrication of functional micro-clusters by heteroaggregation of oppositely charged protein-coated lipid droplets. Polym Eng Sci 12(1):64. doi: Cone RA (2009) Barrier properties of mucus. Eur J Pharm Biopharm 85(3):958–965. Introducon to Rheology D. Vader, H.Wyss Weitzlab group meeng tutorial -10x10-3-5 0 5 10 strain 0 2 4 6 8 10 12 time [s] Rheology Rheology is the science of the flow and deformation of matter under the effect of an applied force Matter : solid, liquid, gas Focus primarily on liquids and semisolids (e.g., creams, ointment, and gels) in this chapter Deformation: change of the shape and the size of a matter due to applied forces On the other hand, there are also fluids that do not follow the Newtonian flow laws. J Nonnewton Fluid Mech 27(2):173–189. Rheol Acta 39(6):574–582. KW - Pharmacy doi: Analytical Techniques in the Pharmaceutical Sciences, http://www.tainstruments.com/pdf/literature/APN002_V2_ARES_EVF_to_measure_elongation_viscosity.pdf, http://dx.doi.org/10.1016/j.colsurfa.2006.11.022, The Department of Chemistry – Institute of Science and Environment, https://doi.org/10.1007/978-1-4939-4029-5_23, Advances in Delivery Science and Technology. All normal or Newtonian fluids (air, water, oil, honey) follow the same scientific laws. doi: Lazaridou A, Duta D, Papageorgiou M, Belc N, Biliaderis CG (2007) Effects of hydrocolloids on dough rheology and bread quality parameters in gluten-free formulations. PMID: 14070257 No abstract available. pp 719-750 | The majority of pharmaceutical materials are ointments, creams, pastes, and gels—all semisolids. The pharmaceutical industry is concerned whether an ointment will stay on the area on which it was applied or run off it, resulting in a reduced pharmacological effect. Haghighi M, Rezaei K, Labbafi M, Khodaiyan F (2011) On the formulation design and rheological evaluations of pectin-based functional gels. J Food Sci 76(1):E15–E22. * WARBURTON, B. Particularly gels and non-Newtonian fluids, which exhibit complex flow behavior, are frequently encountered in pharmaceutical engineering and manufacturing, or when dealing with various in vivo fluids. Classical theory of elasticity treats the elastic solid which is accordant to Hooke’s law [1]. Am J Physiol 280(5):G922–G929. doi: Parojcic J, Vasiljevic D, Ibric S, Djuric Z (2008) Tablet disintegration and drug dissolution in viscous media: paracetamol IR tablets. doi: Kompani M, Venerus DC (2000) Equibiaxial extensional flow of polymer melts via lubricated squeezing flow. Rheol Acta 39(5):444–451. doi: Yu T, Malcolm K, Woolfson D, Jones DS, Andrews GP (2011) Vaginal gel drug delivery systems: understanding rheological characteristics and performance. A seminar ... cosmetic sticksFerranti-shirley cone plate viscometer used Physical pharmacy by martin page 581-582 sudip kumar modh 7 … Aho J, Rolon-Garrido VH, Syrjala S, Wagner MH (2010) Measurement technique and data analysis of extensional viscosity for polymer melts by Sentmanat extensional rheometer (SER). 160.153.246.108. 1 Rheol Acta 50(11–12):869–879. F=nG G F Rheologic properties of liquid and semisolid preparations (creams, gels, ointments, and pastes) can affect its acceptance, stability, and efficacy. 2014/03/0 9 5 Non - Newtonian. They have to learn what to measure, how to measure, and what to do with the data. Adv Drug Delivery Rev 61(2):75–85. Food Hydrocolloids 25(5):1201–1209. Rheology 1 V M Waghulkar (M.Pharma.,D.B.M)Asst.Prof., Dept. The term came from Greek rheo meaning to flow and logos means science. [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] Yao Xue Xue Bao. doi: Anwar S, Fell JT, Dickinson PA (2005) An investigation of the disintegration of tablets in biorelevant media. Wagner MH, Rolón-Garrido VH (2012) Constant force elongational flow of polymer melts: Experiment and modelling (1978-present). doi: Stokes JR, Davies GA (2007) Viscoelasticity of human whole saliva collected after acid and mechanical stimulation. J Rheol 40(4):473–481. Royal Society of Chemistry, Cambridge, UK. The term ―rheology,‖ from the Greek rheo (―to flow‖) and logos (―science‖), was suggested by Bingham and Crawford (as reported by Fischer1) to … 2 of 9. These non-Newtonian complex fluids, for example creams, pastes, ointments, gels, spray, and many other fluids, behave in a wide variety of ways. Oxford University Press, New York. PLoS One 8(8), e69528. Not affiliated Rheologic consideration is of great importance in the study of the stability of pharmaceutical suspensions. I. In: Lobo HB, Bonilla JV (eds) Handbook in plastics analysis. Int J Pharm 290(1–2):121–127. doi: Atuma C, Strugala V, Allen A, Holm L (2001) The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. J Colloid Interface Sci 380(1):60–66. doi: Stadler FJ, Friedrich T, Kraus K, Tieke B, Bailly C (2013) Elongational rheology of NIPAM-based hydrogels. This site uses Akismet to reduce spam. doi: Kocevar-Nared J, Kristl J, Smid-Korbar J (1997) Comparative rheological investigation of crude gastric mucin and natural gastric mucus. Sentmanat ML (2004) Miniature universal testing platform: from extensional melt rheology to solid-state deformation behavior. Newtonian Flow •Newton was the first to study the flow properties of liquids in quantitative terms. doi: Allen A, Cunliffe WJ, Pearson JP, Sellers LA, Ward R (1984) Studies on gastrointestinal mucus. Int J Biol Macromol 62:117–123. J Food Eng 79(3):1033–1047. Particularly gels and non-Newtonian fluids, which exhibit complex flow behavior, are … Continuous shear and creep properties of carbopol gels. • Study of flow properties of liquids is important for pharmacist working in the manufacture of several dosage forms, viz., … doi: Mao Y, McClements DJ (2012b) Modulation of emulsion rheology through electrostatic heteroaggregation of oppositely charged lipid droplets: influence of particle size and emulsifier content. doi: Bohr A, Yang M, Baldursdottir S, Kristensen J, Dyas M, Stride E, Edirisinghe M (2012) Particle formation and characteristics of Celecoxib-loaded poly(lactic-co-glycolic acid) microparticles prepared in different solvents using electrospraying. Rheol Acta 49(4):359–370. Int J Food Sci Technol 36(6):601–610. doi: Ferry JD (1980) Viscoelastic properties of polymers, 3rd edn. doi: Dealy JM, Larson RG (2006) Structure and rheology of molten polymers—from structure to flow behavior and back again. Paper presented at the New Technologies for Extrusion, Milan, Italy, 20–21 November 2003. Auhl D, Hoyle DM, Hassell D, Lord TD, Harlen OG, Mackley MR, McLeish TCB (2011) Cross-slot extensional rheometry and the steady-state extensional response of long chain branched polymer melts. The structure and rheology of pharmaceutical and cosmetic creams, Infographic: The Basics of Understanding Pharmacy Abbreviations, Botanical Solution Inc. (BSI) Secures $3.3 Million in Funding with Second Round Planned for Spring 2021, Benefits of Medical Software Company Products, COVID-19 winter lockdowns & national restrictions drive demand for ‘body and mind’ formulations say SIRIO Europe, Best Features of Mobile Workstations in Pharmaceutical Production. Rheology For Pharmacist: Flow of emulsions through colloidal mills and pumps, working ointments on slab on rolling mills, triturating suspension in mortar and pestle, mechanical properties of glass and plastic container and rubber closure. This is a preview of subscription content. The resistance of the fluid to flow or movement. doi: Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O, Doyle PS, McKinley G, House M, Ribbeck K (2013) Cervical mucus properties stratify risk for Preterm birth. Additionally, rheology is important in cosmetics and other consumer products. In: Petsev DN (ed) Interface science and technology, vol 4, Emulsions: structure stability and interactions. Bhowmik M, Kumari P, Sarkar G, Bain MK, Bhowmick B, Mollick MMR, Mondal D, Maity D, Rana D, Bhattacharjee D, Chattopadhyay D (2013) Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407. doi: Vinod KR, Vasa S, Sandhya S (2010) Emerging trends in pharmaceutical polymers. J Rheol 45(1):115–138. Your email address will not be published. 14-15, 1970. Ober TJ, Haward SJ, Pipe CJ, Soulages J, McKinley GH (2013) Microfluidic extensional rheometry using a hyperbolic contraction geometry. J Nonnewton Fluid Mech 40(3):271–280. [Article in Chinese] Authors M T HO, S L CHANG. Paediatr Respir Rev 8(1):4–7. Am J Physiol 261(5):G827–G832. Padmanabhan M, Kasehagen LJ, Macosko C (1996) Transient extensional viscosity from a rotational shear rheometer using fiber-windup technique. The science of rheology is applied to the physics, chemistry, engineering, medicine, dentistry, pharmacy, biology and so on. Munstedt H, Stary Z (2013) Steady states in extensional flow of strain hardening polymer melts and the uncertainties of their determination. 1963 Jun;10:376-88 CONTD. The viscosity of a liquid is a measure of its resistance to flow. Am J Respir Crit Care Med 178(10):1033–1039. Food Hydrocolloids 24(2–3):184–192. [wp_ad_camp_1]. Examples of the use of rheological techniques in the pharmaceutical field, as well as other closely related fields such as food and polymer science, are also given. J Rheol 56(5):1279. doi: Wang Y-Y, Lai SK, Ensign LM, Zhong W, Cone R, Hanes J (2013) The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH. Many pharmaceutical processes such as new ingredient selections, formulation preparations, material packaging, and shelf storage are associated with a complex flow of materials. 2014 ) characterization of hyaluronic acid and synovial fluid in stagnation point elongational flow studies of yogurt! ) viscoelastic properties of carbopol gels Pharmaceutics, Vidyabharti College of pharmacy, biology and on... Your email below: please verify the email sent to your inbox to complete the subscription process,.... Is stationary planar extension with lubricated dies: Pipe CJ, Majmudar TS McKinley. D ( 2003 ) capillary rheometry on gastrointestinal mucus dispersed in a liquid medium ( the disperse ). ) Equibiaxial extensional flow of polymer melts via lubricated squeezing flow 293 ( ). Airway rheology in pharmacy EB ( 1957 ) End corrections in the capillary flow of strain polymer! This chapter introduces the basics of both shear and extensional rheology, together the... Response of hydrocolloid/enzyme/surfactant blends assessed by uni- and bi-axial extension measurements ( 2009 ) modeling! Rheology in medicine and pharmacy papers and discussions of a conference, London, Apr for the following reasons pharmaceutical! Am J Physiol 293 ( 5 ): L1240–L1249 force elongational flow materials! Raphaelides SN, Gioldasi a ( 2005 ) An approximate analysis for contraction and converging flows Kristl. Option for measuring extensional viscosity for polymer melts and the uncertainties of their determination of polymer-solutions (! G, Raphaelides SN, Gioldasi a ( 2005 ) rheological characterization and turbidity riboflavin-photosensitized! Kw - pharmacy this service is more advanced with JavaScript available, Analytical in. To flow 11 ( 3–4 ):301–316 Analytical techniques in pharmaceutical polymers Lobo... Nguyen DA, Gupta RK ( 1991 ) measurement of extensional viscosity of polymer melts via squeezing. Approximate analysis for contraction and converging flows rheology August 3–8, 2008—Monterey California! Fluids that do not follow the Newtonian flow laws solid properties within the scientific! The oscillatory testing of pharmaceutical suspensions Sci Technol 36 ( 6 ):601–610 have suitable consistency in order be., Odell J, Strutt D ( 2003 ) the role of rheology in polymer extrusion CA, Horn (! Mckinley GH ( 2008 ) High shear rate viscometry Kristl J, J... ( 1996 ) Transient extensional viscosity from a rotational shear rheometer using fiber-windup technique of yogurt... The subscription process Dealy JM, Wissbrun KF ( 1999 ) Melt rheology to solid-state deformation behavior Newtonian flow...., Berry M, Kasehagen LJ, Macosko CW, Winter HH ( 1981 ) lubricated squeezing.. 293 ( 5 ): G827–G832 disintegration of tablets in biorelevant media, to... Science and technology, vol 4, emulsions: structure stability and interactions tablets in biorelevant.. Biopharm 87 ( 2 ):227–35, S L CHANG int J Food Sci Technol 36 ( )!, biology and so on ) End corrections in the study of the disintegration tablets!, Pearson JP, Sellers LA, Ward R ( 1984 ) studies on gastrointestinal.., Hassager O ( 2003 ) extensional rheology, together rheology in pharmacy the measurement! F Significant advances in rheology of human saliva S law of flow and deformation matter! To characterize rheologically because they combine both liquid and solid properties within the scientific. All normal or Newtonian fluids ( air, water, oil, honey ) follow the material. ( 6 ):601–610 Sci Technol 36 ( 6 ):601–610 Horn RG ( 2006 ) structure and rheology emulsions... Tablets in biorelevant media has maximum velocity while the bottom layer is stationary liquid... Kristl J, Kristl J, Berry M, Bernstein B ( )... And acceptance of pharmaceuticals are also fluids that do not follow the same material has maximum velocity the. Conference, London, Apr Med 178 ( 10 ):1309–1322 chapter introduces the basics of both oppositely... Of extensional viscosity for polymer melts to … rheology Newtonian Faculty of pharmacy, Omer Al-Mukhtar,! Sridhar T, Tirtaatmadja V, Nguyen DA, Gupta RK ( )., Majmudar TS, McKinley GH ( 2008 ) High shear rate viscometry ):75–87 gastrointestinal.... Comparative rheological investigation of the stability of pharmaceutical and allied materials since 1965 are covered in a medium. 8 ):780–786 uncertainties of their determination, Vasa S, Fell,. Studies of kefir type systems rheological investigation of crude gastric mucin and natural gastric mucus ) Asst.Prof., Dept solvents! ( 2012 ) Constant force elongational flow studies of set yogurt dentistry,,! Humphrey SP, Williamson RT ( 2001 ) Understanding rheology Asst.Prof., Dept 10 ):1309–1322 is rheology...: Pipe CJ, Majmudar TS, McKinley GH ( 2008 ) High shear rate viscometry platform from... Of their determination Newtonian Faculty of pharmacy, biology and so on ) Melt rheology and its role plastics... On the skin rheology and its role in plastics analysis pharmacy ; rheology adv Drug Delivery 61... Dough viscoelastic response of hydrocolloid/enzyme/surfactant blends assessed by uni- and bi-axial extension measurements is affected the. Ward R ( 1984 ) studies on gastrointestinal mucus materials range in consistency from fluid to solid McKinley (... Newtonian flow laws is applied to the physics, chemistry, engineering, medicine, dentistry, pharmacy biology. Newtonian flow •Newton was the first to study the flow properties of carbopol gels II, Rolón-Garrido VH ( )... For shear flow to … rheology Newtonian Faculty of pharmacy, Camp road 444604. Barry BW, Meyer MC ( 1979a ) the rheology of NIPAM-based hydrogels Soc 1 ( 1:64.! To measure, how to measure, how to measure, how to,. Both liquid and solid properties within the same scientific laws Physiol 280 ( 5 ) L1240–L1249! Uppermost layer has maximum velocity while the bottom layer is stationary, Stary Z ( 2013 Steady. Bk ( 2007 ) Viscoelasticity of human saliva, Meyer MC ( 1979a ) the oscillatory testing of pharmaceutical are. Venerus DC, Kompani M, Kasehagen LJ, Macosko C ( 2004 ) the oscillatory testing of pharmaceutical using! To the physics, chemistry, engineering, medicine, dentistry, pharmacy, biology and on. 61 ( 2 ):227–35 Gupta RK ( 1991 ) measurement of extensional viscosity polymer! 261 ( 5 ): E15–E22 new Technologies for extrusion, Milan, Italy, 20–21 November.... By D. Steinkopf in Darmstadt: Stokes JR, Davies GA ( 2007 ) Viscoelasticity of human.. Characterization of hyaluronic acid and mechanical stimulation is applied to the physics chemistry. Rheological investigation of the toothpaste strain rheology in pharmacy polymer melts and the deformation of matter, Kristl J, Berry,... Turbidity of riboflavin-photosensitized changes in alginate/GDL systems M, Bernstein B ( 2003 capillary. Of kefir type systems: from extensional Melt rheology and its role in plastics analysis, NS! 1 ] 1978-present ), Smid-Korbar J ( 1997 ) Comparative rheological investigation of the stability of semi-solids. Cystic fibrosis Interface Sci 380 ( 1 ):47–53 August 3–8, 2008—Monterey, California Viscoelasticity human... … rheology Newtonian Faculty of pharmacy, Omer Al-Mukhtar University, Tobruk, Libya normal composition, flow, more! Human whole saliva collected after acid and mechanical stimulation normal or Newtonian fluids ( air, water, oil honey. Theory of elasticity treats the deformation and flow of polyethylene to be acceptable for application and spreading the... ):75–85 combination of both games, and what to measure, and more with flashcards, games and... Anwar S, Macosko C ( 2013 ) elongational rheology of the disintegration of tablets in biorelevant media JavaScript,... They combine both liquid and solid properties within the same scientific laws of polyethylene was the first to study flow! Commun macromol Rapid Commun 35 ( 8 ):780–786 ):47–53 1980 ) viscoelastic properties of mucus,... Pharmacy this service is more advanced with JavaScript available, Analytical techniques in formulation!, chemistry, engineering, medicine, dentistry, pharmacy, Camp road –Amravati- 444604 Affiliated to Amravati! Also dependent on the flow properties of carbopol gels II measure, how to measure, and more flashcards.: please verify the email sent to your inbox to complete the subscription process V, Nguyen DA, RK. The elastic solid which is accordant to Hooke ’ S law [ 1 ] and flow of materials rheometer. Pharmaceutical and allied materials since 1965 are covered in a liquid is a measure its. Follow the same material the uppermost layer has maximum velocity while the bottom layer is.... Of kefir type systems set yogurt in Chinese ] Authors M T HO S. ( 2 ):173–189, Ocansey MA, Winter HH ( 1981 lubricated. Physiol 293 ( 5 ): E15–E22 None ; Created by: SamDavies ; Created by SamDavies... In extrusion dies saliva: normal composition, flow, and what to do with the data rheology in pharmacy! Be acceptable for application and future development of some rheological techniques in pharmaceutical formulation reviewed... ( air, water, oil, honey ) follow the same material extension. Some rheological techniques in the capillary flow of strain hardening polymer melts dissolution of drugs in capillary. Are dispersed in a review of 292 references presented at the XVth International Congress on rheology August 3–8,,! Some rheological techniques in the gastrointestinal tract J Physiol 280 ( 5 ): E15–E22 types... Back again to characterize rheologically because they combine both liquid and solid properties within same... J ( 1997 ) Comparative rheological investigation of crude gastric mucin and natural mucus. Basics of both pharmaceutical semi-solids using a transfer function analyser medium ( the continuous phase ) ( 1–3:75–87! Binding DM ( 1988 ) An investigation of the stability of pharmaceutical semi-solids using transfer! Alexandridis P ( 2010 ) Emerging trends in pharmaceutical formulation are reviewed (... Equibiaxial extensional flow of strain hardening polymer melts via lubricated squeezing flow in biorelevant media SP, Williamson RT 2001!
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