The safety of trazodone with alcohol can depend on the dose and the specifics of the patient's case. Severe Interactions. The major food and substances that can cause a major interaction with diphenhydramine is alcohol. Some of these interactions can occur even at moderate drinking levels and result in adverse health effects for the drinker. Alcohol increases the risk of trazodone-related drowsiness and dizziness while trazodone enhances the effects of alcohol. Combining alcohol with trazodone can greatly increase its effects on your nervous system, which can become serious very quickly. Older people also are more likely to take a medication that interacts with alcohol—in fact, they often need to take more than one of these medications. Using diphenhydramine with alcohol shares a similar effect with some of the medication discussed above. Many medications can interact with alcohol, thereby altering the metabolism or effects of alcohol and/or the medication. Taking trazodone together with anesthetic medicines (numbing medicines) that are used during surgery, dental treatments, or emergency treatments may cause an increase in CNS depressant effects. Taking more than one drug at a time can increase your risk of negative interactions. Aging slows the body’s ability to break down alcohol, so alcohol remains in a person’s system longer. Trazodone and alcohol death can occur because both can affect respiration and functionality of the central nervous system. Notes for Professionals: Trazodone may enhance the response to alcohol and other CNS depressants. Mary McMahon Date: January 03, 2021 Taking trazodone with alcohol may worsen feelings of depression.. There’s also a risk of other side effects such as restlessness, mood swings, confusion, and hallucinations. Amitriptyline And Weed Interaction. In this case, alcohol can make the side effects of Zoloft worse. Alcohol can also further impair your judgment when combined with trazodone, which can lead to poor decisions such as taking recreational drugs or choosing to drive while impaired. The severity of drug interaction depends on a number of factors that includes the trazodone dosage and the amount of alcohol taken. Trazodone can have significant sedative effects. Trazodone may cause dry mouth. Warning labels for this drug developed by the manufacturer and approved by regulatory agencies often advise against the use of alcohol because it can make some side effects … Trazodone is one of the most commonly prescribed hypnotic medications in patients with sleep disturbances in alcohol recovery. Side Effects Of Trazodone And Alcohol. Benadryl And Alcohol Interactions. Alcohol is a common cause of heartburn, sour stomach,and indigestion, so you probably don't want to head to happy hour if you're experiencing any … For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. Trazodone on its own rarely causes overdoses, but with trazodone and alcohol, death can occur, particularly when one or both are taken in large doses. Older people are at particularly high risk for harmful alcohol–medication interactions. Does Trazodone HCL Interact with other Medications? These medications are not usually taken together. Alcohol and Medication Interactions Ron Weathermon, Pharm.D., and David W. Crabb, M.D. Alcohol and Zoloft are both drugs. The patient should be cautioned accordingly. A recent study concluded that treating insomnia with trazodone in patients with alcohol dependence might impede improvements in alcohol consumption and lead to increased drinking when trazodone is stopped. 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