Pending Application number JP12573978A Other languages Japanese (ja) Inventor Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. This site needs JavaScript to work properly. Lab tests will be required. Xanthine Derivatives These agents are used as additional therapy for patients who remain in refractory status asthmaticus despite maximal inhalational therapy … U.S. Pat. THE ANTI-ANAPHYLACTIC ACTIVITY OF THEOPHYLLINE AND SOME RELATED XANTHINE DERIVATIVES. a crystalline compound related in structure to uric acid and found in urine, blood, certain plants, and certain animal tissues. google_color_url = "008000"; Children: Safety and effectiveness of aminophylline and theophylline for use in children younger than 1 year of age have not been establish Caution should be exercised for younger children who cannot of side effects. Xanthine CAS registry number (Chemical Abstracts Service) 0000069-89-6. Theophylline is a xanthine derivative. Take 24-hour release products once daily, preferably in the morning. Sustained, Extended, or Controlled Release Products: Take 8- to 12-hour release products at regular intervals (8 or 12 hours) around the clock. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. Try to take at the same time each day. Take exactly as prescribed. Xanthine is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. Also included amongst these are the methylxanthine derivatives caffeine, theobromine and theophylline. These are very closely related and are to be found in extremely varying contents in different plants. Chemical Formula. Acute asthma attacks (status asthmaticus) are a medical emergency and are not rapidly responsive to usual doses of conventional bronchodilators. This makes them useful to treat asthma, emphysema, and chronic bronchitis. Allopurinol and Febuxostat are xanthine oxidase inhibitor drugs that is used to treat gout and high levels of uric acid in the blood (hyperuricemia) caused by certain cancer medications, and kidney stones. What do xanthine drugs do? In contrast, weak staining was observed in skin treated with xanthine derivatives. But, each dynamic and static program for molecular simulation of P-gp action is dividing on input variable, considering mechanistic view of insight drug transport. } // not handled: JScript pre 1900. The present invention relates to pharmaceutical formulations comprising xanthine or xanthine derivatives, kits thereof, and methods for treating fibrotic diseases by local administration. Dyphylline is not recommended for cl1idren. Application Xanthine has been used in a nonradiolabled substrate mix in an Aspergillus nidulans transport assay. To treat bronchospasm (spasm in breathing tubes) associated with chronic bronchitis and emphysema. No. google_color_bg = "B2BABD"; Molecular Weight. Uses: 1. Chronic obstructive pulmonary disease (COPD) is estimated to affect 32 million persons in the United States and is the third leading cause of death in this country. else { // covers JScript from 1900 thru 1999 and JavaScript until 3899 google_ad_client = "pub-4320640034320305"; isnDays[0]="Sun"; Keywords:Methylxanthines, xanthine derivatives, adenosine, adenosine receptors, subtype-selectivity, risk/benefit ratio, theophylline, cardiorespiratory disorders, caffeine, electrophysiological Abstract: Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders, whereas caffeine is the most widely consumed psychoactive agent in various soft drinks. C5-H4-N4-O2. The most widely used xanthine is theophylline. // Build an array initializer USES: This medication improves breathing by opening air passages in the lungs. Xanthine derivative (Dorland, 28th ed) A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. 2010 Sep;29(3):215-21. doi: 10.4149/gpb_2010_03_215. Copyright © 2006 Health-Care-Tips.org. Pregnancy: There are no adequate and well-controlled studies in pregnant women. These compounds are alkaloids and include such common mild stimulants as caffeine and theobromine, which is found in chocolate. Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions Download PDF Info Publication number US7482337B2. NIH Use only if clearly needed and potential benefits outweigh the possible hazards to the fetus. To prevent and relieve symptoms of bronchial asthma. Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. Do not take a different dose, take the drug more often, or for a longer time than prescribed. All of these actions may be important in their effects of bronchial tree, resulting in relaxation of smooth muscle. Xanthine is produced naturally by both plants and animals. Caffeine (present in coffee) and theobromine (present in … HEALTH CARE | ABOUT US | CONTACT US | BLOG. Avoid large amounts of caffeine-containing beverages, such as tea, coffee, cocoa, and cola drinks, or eating large amounts of chocolate. The xanthine derivative 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine (HWA 285) enhances the actions of adenosine. The methylxanthines, theophylline, and dyphylline are used in the treatment of airways obstruction caused by conditions such as asthma, chronic bronchitis, or emphysema. Bronchial asthma b. Osteoporosis c. Dementia d. Pancreatitis Xanthine derivatives are used for prophylaxis and the symptomatic relief of which of the following conditions or disorders? Xanthines are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma symptoms. The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Why the xanthine derivatives are used to study of P-glycoprotein-mediated multidrug resistance in L1210/VCR line cells. For specific medical advice, diagnoses, and treatment, please consult your doctor. The vasodilation caused by xanthines has been used to treat intermittent claudication (pentoxifylline). Acta Pharmacol Toxicol (Copenh). This mini review focuses on the molecular modeling of xanthine derivatives which, in the recent past, has proved to be a promising avenue for structure-based methods of target identification. These are plant alkaloids and components of coffee, tea and chocolate. 1986 Mar;58(3):187-92. doi: 10.1111/j.1600-0773.1986.tb00093.x. The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. The xanthines are very rare causes of drug induced liver injury, most instances being mild and due to a hypersensitivity reaction or due to hepatic ischemia associated with overdose. Nervous System: Seizures; headache; sleeplessness; irritability; restlessness; muscle twitching; reflex hyperexcitability; agitation. Bronchodilators; theophylline products; drugs that make breathing easier by relaxing and widening certain breathing passages (bronchial tubes) of the lung. Organic substances containing nitrogen are widespread throughout the whole of the natural world. US7482337B2 US10/695,597 US69559703A US7482337B2 US 7482337 B2 US7482337 B2 US 7482337B2 US 69559703 A US69559703 A US 69559703A US 7482337 B2 US7482337 B2 US 7482337B2 Notify your doctor if respiratory symptoms return repeatedly near the end of the dosing interval. Methods: Plant extracts containing xanthine derivatives and three xanthine derivatives were topically applied to the dorsal skin of hairless mice, and the mice were exposed to a resemblance of solar ultraviolet irradiation at a dose of 13.0 J/cm(2) (UVA) for 15 weeks, five times a week on weekdays. Dočolomanský P, Boháčová V, Barančík M, Breier A. Gen Physiol Biophys. If stomach upset occurs, it … Xanthine derivatives are present in coffee, tea and cocoa seeds. The xanthine derivatives are administered orally. document.write(1900 + thisyear); This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine receptor antagonistic properties. Xanthines can cause a mild diuresis. 5.14 Xanthine Derivatives Open Resources for Nursing (Open RN) Theophylline is a xanthine derivative. The increase in cAMP causes relaxation of bronchial smooth muscle. Xanthines and its derivatives are a group of alkaloids which are well represented in plants. Taking theophylline immediately after a high-fat meal or a fasting period may alter its rate of absorption. High blood levels of xanthine bronchodilators may cause severe side effects. Pathology. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. Because of the potential for serious adverse reactions in nursing infants, decide whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Indications for Use These medications may be administered intravenously. The major use of xanthine derivatives are for relief of bronchospasm caused by asthma or chronic obstructive lung disease. Store oral dosage forms at room temperature (59° to 86°F) in a tightly closed container. Oxtriphylline is not recommended for children younger than 6 years of age. 1. Interaction of xanthine derivatives with binding site of P-gp is a question which could be solved by experiment; although, molecular modelling may clear up this matter. Xanthine Derivatives. Xanthine derivative Mechanism of Action. Be aware of drug interactions with cimetidine, oral contraceptives, allopurinol, certain antibiotics, influenza vaccine, others 2. Cigarette smoking enhances xanthine metabolism 3. Xanthines also stimulate muscle and cardiac cells and neurons. The present invention relates to pharmaceutical formulations comprising xanthine or xanthine derivatives, kits thereof, and methods for treating fibrotic diseases by local administration. Theo-24 - In patients receiving once-daily doses of 900 mg or more, avoid eating a high-fat morning meal or take at least 1 hour before eating. google_ad_width = 120; If you cannot comply with this regimen, talk to your doctor about alternative therapy. Xanthines are a group of compounds that are derivatives of xanthine, a purine base. 10. This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine receptor antagonistic properties. These activities have potential use in preventing arterial thrombosis and thus prevention of myocardial infarction and stroke. google_ad_format = "120x90_0ads_al"; Uniphyl, Theolair SR - Take this drug consistently with respect to food, either with meals or fasting (at least 2 hours pre- or 2 hours postmeals). The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. Also asked, what is a xanthine derivative? google_ad_channel ="6145589847"; Molecular Weight. var isnMonths=new isnArray("January","February","March","April","May","June","July","August","September","October","November","December"); Clipboard, Search History, and several other advanced features are temporarily unavailable. Take 12- to 24-hour release products generally every 12 hours. Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma or influenza symptoms. Szentmiklósi AJ, Cseppentō A, Gesztelyi R, Zsuga J, Körtvély A, Harmati G, Nánási PP. Individual doses are determined by response (decrease in symptoms) and blood levels (except with dyphylline). Consult your doctor before you begin breastfeeding. Brand interchange - Do not change from one brand of this drug to another without consulting your pharmacist or doctor. If a does Is missed, take the next dose at the usually scheduled time. HHS Xanthine derivatives such as theophylline inhibit phosphodiesterase, resulting in an increase in cAMP. It is suggested that xanthine derivatives prevented neutrophil infiltration caused by UV‐irradiation. Used during acute phase of asthmatic attacks & bronchospasm->quickly reduce airway constriction & restore normal airflow. USA.gov. Xanthine derivatives, including caffeine, prevent adenosine, hexobendine and regadenoson from working. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Interaction of xanthine derivatives with binding site of P-gp is a question which could be solved by experiment; although, molecular modelling may clear up this matter. There is a genetic disease of xanthine metabolism, xanthinuria, due to deficiency of an enzyme, xanthine dehydrogenase, needed to process xanthine in the body. Therapeutic Categories. Xanthines are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma symptoms. Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. C5-H4-N4-O2. Xanthine derivatives in the heart: blessed or cursed? Bronchodilators: Beta-Adrenergic Agonists. Try to take at the same time each day. The xanthines have many minor side effects (anxiety, nervousness, tremor, headache, dizziness) but are largely well tolerated in the doses used to treat asthma and chronic bronchitis. // And months and day arrays Possible side effects include: Digestive Tract: Stomach pain; nausea; vomiting; vomiting of blood; diarrhea; gastroesophageal reflux (nocturnal). The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. XANTHINE DERIVATIVES FOR USE AS DIURETICS (PAT - EP0667777) ADAMUS Stefan, GAIDA Wolfram, MEADE Christopher, KÜFNER-MÜHL Ulrike BOEHRINGER INGELHEIM INTERNATIONAL GmbH. If more than one dose is missed or it is necessary to establish a new dosage schedule, contact your doctor or pharmacist. If stomach upset occurs with liquid preparations or non-sustained release forms, take with food. J Pharm Pharmacol. this[i+1] = isnArray.arguments[i]; Related terms: Adenosine; Enzyme; Protein; … WebMD provides information about interactions between Cafcit Injection and xanthine-derivatives-adenosine-hexobendine-regadenoson. Its analogue, aminophylline, can be given intravenously (IV). It is not a substitute for professional medical advice. Be sure to keep appointments. The methylxanthines, theophylline, and dyphylline are used in the treatment of airways obstruction caused by conditions such as asthma , chronic bronchitis , or emphysema . google_ad_height = 90; Xanthine Derivatives: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape Reference 1988 Aug;94(4):1091-100. doi: 10.1111/j.1476-5381.1988.tb11627.x. These information are not intended to act as a substitute for a professional healthcare practitioner advise. In contrast to other, more potent stimulants like sympathomimetic amines, xanthines mainly act to oppose the actions of adenosine, and increase alertness in the central nervous system. Patients typically have symptoms of chronic bronchitis and emphysema, but the classic triad also includes asthma (see the image below). Nicotine replacement therapy (NRT) used in smoking cessation programs does not adversely affect theophylline clearance.
